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Description | |
Product Name | Simvastatin |
Synonym | [(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate |
Product Information | |
Cas Registration No. | 79902-63-9 |
Chemical Formula | C25H38O5 |
Molecule Weight | 418.57 |
HS Code | |
Application | Simvastatin is a specific inhibitor of HMG-CoA reductase, the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. It is used in the treatment of hypercholesterolemia, as it reduces levels of low-density lipoproteins and triglycerides, and raises high-density lipoprotein levels. Simvastatin is a lactone that is readily hydrolyzed in vivo to the corresponding β-hydroxyacid, and can be activated prior to use with NaOH in EtOH treatment. |
Characteristics | |
Quality Specification | |
Appearance | White to off white Powder |
Dose Form | Oral Grade |
Specification | USP |
Storage / Packing Information | |
Storage | 10℃-30℃ |
Packing Unit | 1KG / 25KG / 100KG / 250KG / 1MT |
Custom Information | |
GMP | GMP, PIC/S |
DMF | DMF in CTD |
Development | Commercialized |