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원료의약품
APIs(Active Pharmaceutical Ingredients)

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  • 등록일 2021. 03. 16

 

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Description
Product Name Simvastatin
Synonym [(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate
 
Product Information
Cas Registration No. 79902-63-9
Chemical Formula C25H38O5
Molecule Weight 418.57
HS Code  
Application Simvastatin is a specific inhibitor of HMG-CoA reductase, the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. It is used in the treatment of hypercholesterolemia, as it reduces levels of low-density lipoproteins and triglycerides, and raises high-density lipoprotein levels. Simvastatin is a lactone that is readily hydrolyzed in vivo to the corresponding β-hydroxyacid, and can be activated prior to use with NaOH in EtOH treatment.
Characteristics  
 
Quality Specification
Appearance White to off white Powder
Dose Form Oral Grade
Specification USP
 
Storage / Packing Information
Storage 10℃-30℃
Packing Unit 1KG / 25KG / 100KG / 250KG / 1MT
 
Custom Information
GMP GMP, PIC/S 
DMF DMF in CTD
Development Commercialized