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APIs(Active Pharmaceutical Ingredients)
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- 등록일 2021. 03. 16
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| Description | |
| Product Name | Simvastatin |
| Synonym | [(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate |
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| Product Information | |
| Cas Registration No. | 79902-63-9 |
| Chemical Formula | C25H38O5 |
| Molecule Weight | 418.57 |
| HS Code | |
| Application | Simvastatin is a specific inhibitor of HMG-CoA reductase, the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. It is used in the treatment of hypercholesterolemia, as it reduces levels of low-density lipoproteins and triglycerides, and raises high-density lipoprotein levels. Simvastatin is a lactone that is readily hydrolyzed in vivo to the corresponding β-hydroxyacid, and can be activated prior to use with NaOH in EtOH treatment. |
| Characteristics | |
| Quality Specification | |
| Appearance | White to off white Powder |
| Dose Form | Oral Grade |
| Specification | USP |
| Storage / Packing Information | |
| Storage | 10℃-30℃ |
| Packing Unit | 1KG / 25KG / 100KG / 250KG / 1MT |
| Custom Information | |
| GMP | GMP, PIC/S |
| DMF | DMF in CTD |
| Development | Commercialized |